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Revolution vs Advantage Multi: Which One is Better?

revolution vs advantage multi

Last Updated: April 17, 2024 by Lisa Melillo

Keeping your furry friend healthy and happy involves feeding, exercise, grooming, mental stimulation, and effective parasite control. As someone who has spent countless hours dealing with the aftermath of infestations, I know first-hand how critical this aspect of care is.

For instance, fleas can infest your pet, take over your furniture, yard, and carpet, and even bite you. When your dog scratches and chews at fleas, there’s a risk it could swallow them, potentially ingesting tapeworm eggs or harmful bacteria. It’s a situation that’s as gross as it sounds, and trust me, it’s something you want to avoid.

But fleas aren’t the only pests you need to worry about. Heartworms, transmitted by mosquitoes, travel through your pet’s bloodstream and eventually crowd the heart and lungs, growing into adults. And let’s not forget ticks—these little critters can transmit diseases like Rocky Mountain Spotted Fever and Lyme Disease, which can also be passed on to humans.

Many pet owners hesitate to administer medication when a pet is healthy, but I’ve learned that preventative measures are key. Medication that kills these insects and worms keeps your pets safe from infestations, which are always easier to prevent than to treat.

Among the top options for preventing these parasites are Revolution and Advantage Multi. Both products are widely used and trusted in the veterinary community. This Revolution vs. Advantage Multi review will help you decide which medication suits your pet.

Revolution’s History in Brief

revolution plus

Revolution, also known by its scientific name Selamectin, is a topical medication developed for treating and preventing various parasites in dogs and cats. I found out that it was introduced by Pfizer Animal Health, now known as Zoetis, and has become one of the most trusted names in pet parasite control since its approval by the FDA in the early 2000s.

After rigorous testing for efficacy and safety, Selamectin was approved in the U.S. in 1999, marking a significant advancement in veterinary medicine. Since its market introduction, Revolution has been widely adopted by veterinarians and pet owners alike due to its broad-spectrum efficacy and ease of use. It is especially popular for its once-a-month dosing, which simplifies the regimen for pet owners and increases compliance. In recent years, Zoetis has continued to innovate and expand the Revolution product line with Revolution Plus, which offers enhanced protection against additional parasites like ticks and more types of mites.

Revolution Product Lines

Revolution Topical Solution

The core product, Revolution Topical Solution for Dogs, is categorized based on pet weight, ensuring that each pet receives a safe and effective dosage for their size:

You’ll need to chat with your vet about the dosage strength you need for dogs more massive than 130 lbs.

Each formula is intended to be applied once monthly to the skin between the shoulder blades. While not universally available in all regions, Revolution Plus expands upon the original formula by offering broader protection that may include additional types of ticks and other parasites, catering to the needs of dog owners in areas with higher tick populations or varied parasitic threats.

Advantage Multi’s History in Brief


Advantage Multi

Advantage Multi, also known as Advocate in some countries, is a broad-spectrum parasite prevention medication developed by Bayer Animal Health, now part of Elanco. It was introduced in the early 2000s to provide a more comprehensive solution for pet owners seeking to protect their dogs and cats from several parasites.

Advantage Multi Product Lines

Advantage Multi

The active ingredients in Advantage Multi, imidacloprid, and moxidectin, work synergistically to treat and prevent multiple parasitic infections. It kills fleas, prevents heartworm disease, and treats gastrointestinal worms. Advantage Multi is applied topically once a month and is praised for its ease of use and effectiveness in a single dose:


Revolution vs Advantage Multi: The Differences

Choosing the right medication is crucial for the health and comfort of your pet. Let’s dive into the details and see how Revolution stacks up against Advantage Multi.

Types of Parasites Controlled

Revolution is effective against several key parasites in dogs. It protects against fleas and their eggs, preventing infestations and the associated itching and discomfort. Further, it also prevents heartworm disease, a serious and potentially fatal condition transmitted by mosquitoes. Additionally, Revolution treats sarcoptic mange and ear mites, which can cause severe skin and ear issues, respectively. It’s also effective against the American dog tick, helping to prevent tick-borne illnesses such as Rocky Mountain Spotted Fever.

Advantage Multi, while also providing comprehensive parasite control, has a different emphasis on its protection. Like Revolution, it offers prevention against heartworm disease and treats flea infestations. However, it stands out by treating a broader range of intestinal parasites including hookworms, roundworms, and whipworms, which are common and can harm a dog’s gastrointestinal health. Unlike Revolution, Advantage Multi does not provide any protection against ticks.

Active Ingredients

Revolution uses Selamectin as its primary active ingredient. It’s a potent parasiticide that targets the nervous system of parasites, effectively paralyzing and then killing them. Selamectin is a single-agent solution that simplifies the control of multiple pests, including fleas, heartworms, ear mites, sarcoptic mange, and certain ticks.

Advantage Multi, on the other hand, combines two active ingredients: Imidacloprid and Moxidectin. Imidacloprid focuses on fleas by attacking their nervous system, which quickly leads to their death before they can lay eggs. Moxidectin works by enhancing the release of neurotransmitters that paralyze and kill internal parasites like heartworms, hookworms, roundworms, and whipworms. This dual-action approach addresses both external and internal parasites effectively.

Ease of Use

Revolution and Advantage Multi are designed with ease of use in mind, simplifying the monthly ritual of parasite control for pet owners. Each product is available in a pre-measured, single-dose applicator tube, which you apply directly to the skin, reducing the mess and guesswork often associated with dosing liquid medications.

Revolution offers a slight advantage in terms of overall convenience due to its broader spectrum of parasite control. Since it tackles external and certain internal parasites and heartworms, it can potentially reduce the need for additional products. This makes it especially handy for pet owners looking for a comprehensive, all-in-one solution.

Advantage Multi, while equally easy to apply, may require pet owners to supplement with an additional tick prevention product if they live in areas where ticks are prevalent. This could add an extra step to the monthly parasite prevention routine, slightly complicating the process compared to using Revolution.

Safety Profile

Revolution has a well-established safety record. It is approved for use in dogs as young as six weeks, which indicates its safety for puppies. Additionally, it has been tested and approved, demonstrating its safety across various life stages. Common side effects are minimal but may include temporary irritation at the application site, such as redness or hair loss, which is usually mild and resolves quickly without intervention.

Advantage Multi also maintains a strong safety profile and is similarly approved for use in young puppies from seven weeks of age. The combination of imidacloprid and moxidectin in Advantage Multi is generally well-tolerated; however, some dogs may experience side effects such as gastrointestinal discomfort due to its broader internal parasite control, which can occasionally include symptoms like vomiting or diarrhea.

Availability and Prescription Requirements

Both Revolution and Advantage Multi are widely available through veterinarians, which means you can’t just pick them up over the counter. They require a prescription, which ensures your vet evaluates your dog for suitability and safety. The need for a heartworm test before starting either treatment is standard, as is the recommendation for annual check-ups to continue using these products.

Revolution vs Advantage Comparison

Revolution Topical Solution for Dogs


  • Comprehensive protection against fleas, heartworms, ear mites, sarcoptic mange, and certain ticks
  • Breaks the flea life cycle by preventing egg development
  • Approved for use in dogs of all ages, including puppies as young as six weeks
  • Requires only one monthly application
  • Can be used in dogs and cats, simplifying parasite control for multi-pet households


  • Does not protect against whipworms and some other intestinal worms
  • Must be applied to an area where pets cannot lick it off, requiring careful application
  • May cause temporary irritation at the application site

Advantage Multi


  • Provides broad-spectrum protection against fleas, heartworms, hookworms, roundworms, and whipworms
  • Particularly effective in preventing heartworm disease
  • Kills fleas before they lay eggs
  • Approved for use in young puppies from seven weeks of age
  • Offers added protection against a range of intestinal parasites not covered by some other brands


  • Does not protect against ticks, which may require an additional product for tick prevention
  • Can cause side effects such as gastrointestinal discomfort in some dogs
  • Needs careful handling to avoid oral ingestion by the pet or children
  • Requires a prescription, which means a vet visit and possibly additional costs

FAQs about Revolution and Advantage Multi

What is the difference between Revolution and Advantage Multi?

Revolution and Advantage Multi are topical parasite prevention treatments, but they differ significantly in terms of the parasites they target and their active ingredients. Revolution, using Selamectin, primarily targets fleas, heartworms, ear mites, sarcoptic mange, and certain ticks. Advantage Multi, on the other hand, utilizes a combination of Imidacloprid and Moxidectin to protect against fleas and heartworms. It also treats and controls internal parasites like hookworms, roundworms, and whipworms.

How often should I apply Revolution or Advantage Multi?

Both Revolution and Advantage Multi are designed for monthly applications. This consistent schedule helps maintain an effective barrier against parasites and ensures continuous protection for your dog. It’s important to apply these treatments every 30 days as directed to optimize their efficacy against the targeted parasites.

Are there any side effects associated with Revolution or Advantage Multi?

Both Revolution and Advantage Multi are generally well-tolerated by most dogs. However, as with any medication, some dogs may experience side effects. Common side effects of Revolution include temporary irritation at the application site, such as redness or hair loss. For Advantage Multi, some dogs might experience gastrointestinal symptoms like vomiting or diarrhea, especially if they are sensitive to the active ingredients. Contact your veterinarian if you notice any persistent or severe reactions after applying these products.

Do I need a prescription for Revolution or Advantage Multi?

Yes, Revolution and Advantage Multi require a prescription from a licensed veterinarian. This requirement ensures that your dog is appropriately assessed, considering their health status, age, and the specific parasite risks in your area.

You may also want to check out other comparisons of dog care products on WoofWhiskers: Trifexis vs Sentinel and Credelio vs NexGard.

Final Woof

Both of these products are high-quality, and I’ve personally used each in the past. I appreciate some features Advantage Multi offers, particularly its broad protection. However, when it comes to the variety of parasites Revolution treats and controls, it tends to be more comprehensive in prevention.

Heartworm protection is essential for me, and both brands perform well in this area. Annual heartworm testing for my dog doesn’t bother me—I see it as a crucial step to ensure the effectiveness of the medication. Moreover, since my dog frequently explores the woods on our property where ticks are prevalent, I need reliable tick control. Revolution helps manage this risk, which is a huge relief because I don’t want my dog—or myself—to fall ill from tick-borne diseases.

Revolution also breaks the flea life cycle by stopping eggs from maturing, which is a critical feature for me. Although I’ll still need to manage the fleas that might hitch a ride on my shoes or linger in the carpet and furniture, I feel this is a manageable routine.

While Advantage Multi is effective against whipworms, Revolution covers hookworms and roundworms, which aligns better with my needs. It might mean I have to deworm my pets later, but it’s a trade-off I’m willing to make considering the overall benefits of Revolution.

One concern is the risk of my pets licking off the medication. Revolution needs to be applied in a spot where they can’t reach it, and thankfully, there’s no need to separate them after application, making it less of a hassle and safer around the house.

Therefore, Revolution is my preferred product here. I feel better with it on my pets. It’s the clear winner.



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